The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke-Reference-Cited by-同舟云学术

The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke

Published:2024-03-12 Issue:6 Volume:67 Page:4676-4690
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Evans Ryan¹,Bolduc Philippe N.¹^ORCID,Pfaffenbach Magnus¹^ORCID,Gao Fang¹,May-Dracka Tricia¹,Fang Terry²,Hopkins Brian T.¹^ORCID,Chodaparambil Jayanth V³,Henry Kate L.²,Li Pei⁴^ORCID,Metrick Claire³,Nelson Ashley²,Trapa Patrick⁴,Thomas Ankur²,Burkly Linda²,Peterson Emily A.¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States

2. Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States

3. Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States

4. Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02226

Reference28 articles.

1. Past, Present, and Future of Traumatic Brain Injury Research

2. Ischaemic stroke

3. Traumatic brain injury in the new millennium: new population and new management

4. Dual Functions of Microglia in Ischemic Stroke

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