Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2
Author:
Affiliation:
1. BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.
2. Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Funder
Innovate UK
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00710
Reference34 articles.
1. Phage-encoded combinatorial chemical libraries based on bicyclic peptides
2. The Role of ACE2 in Cardiovascular Physiology
3. A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
4. Angiotensin-Converting Enzyme II in the Heart and the Kidney
5. Angiotensin-Converting Enzyme-2 (ACE2): Comparative Modeling of the Active Site, Specificity Requirements, and Chloride Dependence
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1. Radiotracers for Molecular Imaging of Angiotensin-Converting Enzyme 2;International Journal of Molecular Sciences;2024-08-30
2. Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin;Journal of Medicinal Chemistry;2024-01-29
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