Inclusion of Control Data in Fits to Concentration–Response Curves Improves Estimates of Half-Maximal Concentrations-Reference-Cited by-同舟云学术

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Inclusion of Control Data in Fits to Concentration–Response Curves Improves Estimates of Half-Maximal Concentrations

Published:2023-09-12 Issue:18 Volume:66 Page:12751-12761
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

La Van Ngoc Thuy¹^ORCID,Nicholson Stanley²,Haneef Amna¹,Kang Lulu²^ORCID,Minh David D. L.³^ORCID

Affiliation:

1. Department of Biology, Illinois Institute of Technology, Chicago, Illinois 60616, United States

2. Department of Applied Mathematics, Illinois Institute of Technology, Chicago, Illinois 60616, United States

3. Department of Chemistry, Illinois Institute of Technology, Chicago, Illinois 60616, United States

Funder

National Science Foundation

Pritzker Institute of Biomedical Science and Engineering

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00107

Reference23 articles.

1. Optimizing Classification of Drug-Drug Interaction Potential for CYP450 Isoenzyme Inhibition Assays in Early Drug Discovery

2. Assay Guidance Manual eBook; Markossian, S. , Eds. Eli Lilly & Company and the National Center for Advancing Translational Sciences: Bethesda, MD, 2004. https://www.ncbi.nlm.nih.gov/books/NBK53196/ (accessed 2022-07-01).

3. Assay Guidance Manual; National Center for Advancing Translational Sciences: Bethesda, MD, 2016. https://ncats.nih.gov/expertise/preclinical/agm (accessed 2022-07-01).

4. Guidelines for accurate EC50/IC50 estimation

5. The impact of data transformations on concentration–response modeling

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