Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen-Reference-Cited by-同舟云学术

Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen

Published:2023-10-02 Issue:20 Volume:66 Page:14133-14149
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shell Devan J.¹^ORCID,Foley Caroline A.¹^ORCID,Wang Qinhong²,Smith Chelsea M.³,Guduru Shiva K. R.¹,Zeng Hong⁴,Dong Aiping⁴,Norris-Drouin Jacqueline L.¹,Axtman Matthew¹,Hardy P. Brian¹,Gupta Gaorav²³,Halabelian Levon⁴⁵^ORCID,Frye Stephen V.¹²^ORCID,James Lindsey I.¹²^ORCID,Pearce Kenneth H.¹²^ORCID

Affiliation:

1. UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

3. Lineberger Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

4. Structural Genomics Consortium, University of Toronto, Ontario M5S 1A1, Canada

5. Department of Pharmacology and Toxicology, University of Toronto, Ontario M5S 1A1, Canada

Funder

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

Bayer

Merck KGaA

Genentech

Pfizer

Innovative Medicines Initiative

Bristol-Myers Squibb

Genome Canada

Boehringer Ingelheim