Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-<i>d</i>]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles-Reference-Cited by-同舟云学术

Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles

Published:2023-05-31 Issue:13 Volume:66 Page:8643-8665
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Zhao¹,Sharma Prem Prakash²,Rathi Brijesh²^ORCID,Xie Minghui¹,De Clercq Erik³^ORCID,Pannecouque Christophe³,Kang Dongwei¹⁴^ORCID,Zhan Peng¹⁴^ORCID,Liu Xinyong¹⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P. R. China

2. Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College, University of Delhi, Delhi 110007, India

3. Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), Leuven B-3000, Belgium

4. China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, Jinan, Shandong 250012, P. R. China

Funder

Ministry of Science and Technology of the People's Republic of China

Taishan Scholar Foundation of Shandong Province

Shandong University

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Department of Science and Technology of Shandong Province

Foreign cultural and educational experts Project

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine