Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy-Reference-Cited by-同舟云学术

Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy

Published:2024-02-13 Issue:5 Volume:67 Page:4083-4099
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xu Yongling¹,Du Huijie¹,Guo Weibo¹²,Liu Beibei¹,Yan Wenxin¹,Zhang Chi²,Qin Long²,Huang Jingling¹,Wang Hongxia¹,Wu Shiqi¹,Ren Weijie¹^ORCID,Zou Yi¹^ORCID,Wang Jie³,Zhu Qihua¹^ORCID,Xu Yungen¹^ORCID,Gu Hongfeng¹^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China

2. Xi’an Xintong Pharmaceutical Research Co., Ltd, Xi’an 710061, China

3. China Pharmaceutical University Center for Analysis and Testing, China Pharmaceutical University, Nanjing 211198, China

Funder

Fundamental Research Funds for the Central Universities

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02362

Reference34 articles.

1. Paradigm shift in oncology: targeting the immune system rather than cancer cells

2. Immunotherapy revolutionises non-small-cell lung cancer therapy: Results, perspectives and new challenges

3. PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

4. Immunomodulators targeting the PD-1/PD-L1 protein-protein interaction: From antibodies to small molecules

5. Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

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