A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region-Reference-Cited by-同舟云学术

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A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region

Published:2024-06-06 Issue:12 Volume:67 Page:9857-9868
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gialama Dimitra¹,Vadukul Devkee M.¹^ORCID,Thrush Rebecca J.¹²,Radford Sheena E.³^ORCID,Aprile Francesco A.¹²^ORCID

Affiliation:

1. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.

2. Institute of Chemical Biology, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.

3. Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, U.K.

Funder

Research Councils UK

Royal Society

UK Research and Innovation

Alzheimer's Society

Alzheimer's Research UK

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02408

Reference58 articles.

1. Improving Antibody Therapeutics by Manipulating the Fc Domain: Immunological and Structural Considerations

2. Sagacious epitope selection for vaccines, and both antibody-based therapeutics and diagnostics: tips from virology and oncology

3. Phage Display Libraries for Antibody Therapeutic Discovery and Development

4. Ribosome Display: A Potent Display Technology used for Selecting and Evolving Specific Binders with Desired Properties

5. Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

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