Lies and Liabilities: Computational Assessment of High-Throughput Screening Hits to Identify Artifact Compounds-Reference-Cited by-同舟云学术

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Lies and Liabilities: Computational Assessment of High-Throughput Screening Hits to Identify Artifact Compounds

Published:2023-09-07 Issue:18 Volume:66 Page:12828-12839
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Alves Vinicius M.¹^ORCID,Yasgar Adam²^ORCID,Wellnitz James¹^ORCID,Rai Ganesha²^ORCID,Rath Marielle¹,Braga Rodolpho C.³,Capuzzi Stephen J.¹,Simeonov Anton²,Muratov Eugene N.¹⁴^ORCID,Zakharov Alexey V.²^ORCID,Tropsha Alexander¹^ORCID

Affiliation:

1. Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

2. National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

3. InsilicAll, Sao Paulo, SP 04571, Brazil

4. Department of Pharmaceutical Sciences, Federal University of Paraiba, Joao Pessoa, PB 58059, Brazil

Funder

Foundation for the National Institutes of Health

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00482

Reference47 articles.

1. Impact of high-throughput screening in biomedical research

2. Apparent activity in high-throughput screening: origins of compound-dependent assay interference

3. Frequent hitters: nuisance artifacts in high-throughput screening

4. Fluorescence Spectroscopic Profiling of Compound Libraries

5. High-Throughput Identification of Promiscuous Inhibitors from Screening Libraries with the Use of a Thiol-Containing Fluorescent Probe

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