Discovery and Structural Optimization of Novel Quinolone Derivatives as Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors

Author:

Hu Shihe1ORCID,Liu Yu1,Ma Jiye1,Ding Weijie1,Chen Hua1,Jiang Haifang1,Chen Hongxing1,Wei Song1,Liu Yonggao1,Jin Qiaomei23ORCID,Yuan Haoliang4ORCID,Yan Libo1

Affiliation:

1. SkyRun Pharma Co., Ltd., No. 9 Weidi Road, Nanjing 210046, P. R. China

2. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, P. R. China

3. Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, P. R. China

4. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China

Funder

Nanjing University of Chinese Medicine

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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