Identification of Piperazinyl–Difluoro-indene Derivatives Containing Pyridyl Groups as Potent FGFR Inhibitors against FGFR Mutant Tumor: Design, Synthesis, and Biological Evaluation-Reference-Cited by-同舟云学术

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Identification of Piperazinyl–Difluoro-indene Derivatives Containing Pyridyl Groups as Potent FGFR Inhibitors against FGFR Mutant Tumor: Design, Synthesis, and Biological Evaluation

Published:2024-01-31 Issue:4 Volume:67 Page:2941-2962
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ding Wei¹,Yan Liting²,Sheng Li¹,Chen Shuting²,Li Ying²,Cheng Shihao¹,Luo Lijun¹,Huang Haihong¹,Shao Huanjie²,Zhang Dongfeng¹^ORCID

Affiliation:

1. Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P. R. China

2. College of Life Sciences, Shaanxi Normal University, Xi’an 710119, P. R. China

Funder

Chinese Academy of Medical Sciences

National Natural Science Foundation of China

Natural Science Foundation of Shaanxi Province

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02040

Reference28 articles.

1. Mechanisms of FGFR-mediated carcinogenesis

2. Evidence that FGFRL1 contributes to congenital diaphragmatic hernia development in humans

3. Cellular signaling by fibroblast growth factor receptors

4. The Fibroblast Growth Factor signaling pathway

5. FGFR signaling and endocrine resistance in breast cancer: Challenges for the clinical development of FGFR inhibitors

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