Discovery of an Ortho-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect

Author:

Li Zixiang1,Ye Rufeng23,He Qian1,Lu Jiashuo24,Sun Yanting5,Sun Xiujian5,Tang Siyuan1,Hu Shuyang2,Chai Jingrui2,Kong Linghui1ORCID,Liu Xiaoning6,Chen Jing2,Fang Yun1,Lan Yingjie1,Xie Qiong1ORCID,Liu Jinggen235,Shao Liming1ORCID,Fu Wei1ORCID,Wang Yujun236,Li Wei1ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, China

2. CAS Key Laboratory of Receptor Research and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Road, Shanghai 201203, China

3. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China

4. Department of Pharmacy, Dalian Medical University, Dalian 116044, China

5. Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurobiology of Zhejiang Province, Hangzhou 310053, China

6. Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, Shandong, China

Funder

Ministry of Science and Technology of the People's Republic of China

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Shenzhen-Hong Kong Institute of Brain Science

Shenzhen Fundamental Research Institutions

Publisher

American Chemical Society (ACS)

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