FFLOM: A Flow-Based Autoregressive Model for Fragment-to-Lead Optimization-Reference-Cited by-同舟云学术

FFLOM: A Flow-Based Autoregressive Model for Fragment-to-Lead Optimization

Published:2023-07-20 Issue:15 Volume:66 Page:10808-10823
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jin Jieyu¹,Wang Dong¹,Shi Guqin²,Bao Jingxiao²,Wang Jike¹,Zhang Haotian¹,Pan Peichen¹^ORCID,Li Dan¹^ORCID,Yao Xiaojun³^ORCID,Liu Huanxiang⁴^ORCID,Hou Tingjun¹^ORCID,Kang Yu¹^ORCID

Affiliation:

1. Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China

2. Shanghai Qilu Pharmaceutical R&D Center, 576 Libing Road, Pudong New Area District, Shanghai 310115, China

3. State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau 999078, China

4. Faculty of Applied Science, Macao Polytechnic University, Macau 999078, China

Funder

National Key Research and Development Program of China

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Shanghai Qilu Pharmaceutical Research and Development Centre

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine