Design, Synthesis, and Biological Evaluation of Novel Thioureidobenzamide (TBA) Derivatives as HBV Capsid Assembly Modulators-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Novel Thioureidobenzamide (TBA) Derivatives as HBV Capsid Assembly Modulators

Published:2023-10-15 Issue:20 Volume:66 Page:13968-13990
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Mei¹^ORCID,Zhang Jian¹,Dou Yutong²,Liang Minghui¹,Xie Yong³,Xue Peng⁴,Liu Linyue¹,Li Chuanju⁵,Wang Yuanze⁶,Tao Feiyan⁴,Zhang Xiaohui⁷⁸,Hu Huili⁷⁸,Feng Kairui¹,Zhang Lei¹,Wu Zhuanchang²,Chen Yunfu³,Zhan Peng⁹,Jia Haiyong¹^ORCID

Affiliation:

1. School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, P. R. China

2. Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province and Dept. Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, Jinan 250012, Shandong, P. R. China

3. State Key Laboratory of Anti-Infective Drug Development (NO. 2015DQ780357), Sunshine Lake Pharma Co., Ltd, Dongguan 523871, P. R. China

4. School of Public Health, Weifang Medical University, Weifang 261053, Shandong, P. R. China

5. Department of Pharmacy, Affiliated Hospital of Jining Medical University, Jining 272000, Shandong, P. R. China

6. Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou 510000, Guangdong, P. R. China

7. Key Laboratory of Experimental Teratology, Ministry of Education and Department of Genetics, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, Jinan 250012, P. R. China

8. The Research Center of Stem Cell and Regenerative Medicine, Department of Systems Biomedicine, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China

9. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P. R. China

Funder

Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China

Department of Science and Technology of Shandong Province

Taishan Scholar Foundation of Shandong Province

Weifang Medical University

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01022

Reference47 articles.

1. World Health Organization. Hepatitis B 2022 https://www.who.int/zh/news-room/fact-sheets/detail/hepatitis-b.

2. Hepatitis B virus–host interactions and novel targets for viral cure

3. The scientific basis of combination therapy for chronic hepatitis B functional cure

4. Tenofovir–disoproxil–fumarate modulates lipid metabolism via hepatic CD36/PPAR-alpha activation in hepatitis B virus infection