Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development
Author:
Affiliation:
1. Aileron Therapeutics, Inc., 738 Main Street #398, Waltham, Massachusetts 02451, United States
2. Roche Research Center, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00623
Reference74 articles.
1. Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis
2. Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
3. Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges
4. Targeting intracellular protein–protein interactions with macrocyclic peptides
5. Utilization of macrocyclic peptides to target protein-protein interactions in cancer
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