Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning-Reference-Cited by-同舟云学术

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning

Published:2023-11-23 Issue:23 Volume:66 Page:16051-16061
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ahmad Shabbir¹,Xu Jin²,Feng Jianwen A.²,Hutchinson Ashley¹,Zeng Hong¹,Ghiabi Pegah¹,Dong Aiping¹,Centrella Paolo A.³,Clark Matthew A.³,Guié Marie-Aude³,Guilinger John P.³,Keefe Anthony D.³,Zhang Ying³,Cerruti Thomas⁴,Cuozzo John W.⁴^ORCID,von Rechenberg Moritz⁴,Bolotokova Albina¹,Li Yanjun¹,Loppnau Peter¹,Seitova Alma¹,Li Yen-Yen¹,Santhakumar Vijayaratnam¹^ORCID,Brown Peter J.⁵^ORCID,Ackloo Suzanne¹^ORCID,Halabelian Levon¹⁶^ORCID

Affiliation:

1. Structural Genomics Consortium, University of Toronto, Ontario M5G 1L7, Canada

2. Google Research, Mountain View, California 94043, United States

3. X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02435, United States

4. Relay Therapeutics, 399 Binney Street, Cambridge, Massachusetts 02139, United States

5. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

6. Department of Pharmacology and Toxicology, University of Toronto, Toronto M5S 1A8, Ontario, Canada

Funder

Genome Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01471

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