Discovery of Novel 2,3-Dihydro-1<i>H</i>-indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis-Reference-Cited by-同舟云学术

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Discovery of Novel 2,3-Dihydro-1H-indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis

Published:2023-11-29 Issue:23 Volume:66 Page:16141-16167
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sun Simin¹,Li Zhuoyue¹²,Huang Chao¹,Liu Jinyu¹,Yu Qixin³,Jiang Xiaolin¹²,Yue Kairui¹,Zhao Jianchun¹,Xu Tongqiang³,Liu Yankai¹^ORCID,Li Xiaoyang¹²³,Qin Chong¹²³^ORCID,Jiang Yuqi¹²³^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China

2. Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao, Shandong 266003, China

3. Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong 266071, P.R. China

Funder

Ocean University of China

Taishan Scholar Project of Shandong Province

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Key Technology Research and Development Program of Shandong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01511

Reference53 articles.

1. The NLRP3 inflammasome: molecular activation and regulation to therapeutics

2. Inflammasomes: mechanism of action, role in disease, and therapeutics

3. NLRP3 inflammasome in cancer and metabolic diseases

4. The inflammasome: an integrated view

5. NLRP3 inflammasome activation and cell death

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