Rational Design of Sulfonyl-γ-AApeptides as Highly Potent HIV-1 Fusion Inhibitors with Broad-Spectrum Activity-Reference-Cited by-同舟云学术

Rational Design of Sulfonyl-γ-AApeptides as Highly Potent HIV-1 Fusion Inhibitors with Broad-Spectrum Activity

Published:2023-09-14 Issue:18 Volume:66 Page:13319-13331
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xue Songyi¹,Xu Wei²,Wang Lei¹,Xu Ling²,Calcul Laurent¹,Teng Peng¹^ORCID,Lu Lu²,Jiang Shibo²^ORCID,Cai Jianfeng¹^ORCID

Affiliation:

1. Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States

2. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China

Funder

University of South Florida

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01412

Reference60 articles.

1. World Health Organization. HIV. July 2022 https://www.who.int/data/gho/data/themes/hiv-aids (accessed July 5, 2022).

2. Design of Novel HIV-1/2 Fusion Inhibitors with High Therapeutic Efficacy in Rhesus Monkey Models

3. HIV-1 Antiretroviral Drug Therapy

4. Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection

5. A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein

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