Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors

Published:2023-11-18 Issue:23 Volume:66 Page:16018-16031
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Korff Marvin¹²,Chaudhary Ahmad¹,Li Yinlong¹,Zhou Xin¹,Zhao Chunyu¹,Rong Jian¹^ORCID,Chen Jiahui¹^ORCID,Xiao Zhiwei¹,Elghazawy Nehal H.³,Sippl Wolfgang³^ORCID,Davenport April T.⁴,Daunais James B.⁴,Wang Lu⁵^ORCID,Abate Carmen⁶^ORCID,Ahmed Hazem⁷^ORCID,Crowe Ron¹,Schmidt Thomas J.⁸,Liang Steven H.¹^ORCID,Ametamey Simon M.⁷^ORCID,Wünsch Bernhard²^ORCID,Haider Ahmed¹⁹¹⁰^ORCID

Affiliation:

1. Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States

2. Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, Münster D-48149, Germany

3. Institute of Pharmacy, Department of Medicinal Chemistry, Martin-Luther-University Halle-Wittenberg, W.-Langenbeck-Str. 4, Halle 06120, Germany

4. Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, United States

5. Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China

6. Dipartimento di Farmacia-Scienze Del Farmaco, Università Degli Studi di Bari ALDO MORO, Via Orabona 4, Bari 70125, Italy

7. Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Institute of Pharmaceutical Sciences ETH, Vladimir-Prelog-Weg 4, Zurich 8093, Switzerland

8. Institut für Pharmazeutische Biologie und Phytochemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, Münster D-48149, Germany

9. Department of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, Zurich 8091, Switzerland

10. Department of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States

Funder

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Deutsche Forschungsgemeinschaft

National Institute on Aging

National Institute of Mental Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01441

Reference70 articles.

1. Glutamate Receptor Ion Channels: Structure, Regulation, and Function

2. A structural biology perspective on NMDA receptor pharmacology and function

3. Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

4. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

5. Magnesium gates glutamate-activated channels in mouse central neurones