Design, Synthesis, and Evaluation of Novel Δ<sup>2</sup>-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant <i>Mycobacterium tuberculosis</i> Mutant-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Novel Δ²-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant

Published:2023-07-24 Issue:16 Volume:66 Page:11056-11077
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sarkar Souvik¹^ORCID,Mayer Bridwell Anne E.²,Good James A. D.¹^ORCID,Wang Erin R.²,McKee Samuel R.²,Valenta Joy²,Harrison Gregory A.²,Flentie Kelly N.²,Henry Frederick L.²,Wixe Torbjörn¹,Demirel Peter¹,Vagolu Siva K.³,Chatagnon Jonathan⁴,Machelart Arnaud⁴,Brodin Priscille⁴^ORCID,Tønjum Tone³⁵^ORCID,Stallings Christina L.²,Almqvist Fredrik¹^ORCID

Affiliation:

1. Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden

2. Department of Molecular Microbiology, Center for Women’s Infectious Disease Research, Washington University School of Medicine, St. Louis, 63110 Missouri, United States

3. Department of Microbiology, University of Oslo, N-0316 Oslo, Norway

4. University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000 Lille, France

5. Oslo University Hospital, N-0424 Oslo, Norway

Funder

Agence Nationale de la Recherche

Vetenskapsrådet

Kempe Foundation

Forskningsrådet om Hälsa, Arbetsliv och Välfärd

Norges Forskningsråd

Joint Programming Initiative on Antimicrobial Resistance

Fondation pour la Recherche Médicale

Burroughs Wellcome Fund

Familjen Erling-Perssons Stiftelse

National Institutes of Health

National Institute of General Medical Sciences

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00358

Reference29 articles.

1. World Health Organization. Global Tuberculosis Report 2021, 2021. https://www.who.int/publications-detail-redirect/9789240037021 (accessed Oct 18, 2021).

2. World Health Organization. WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment-Drug-Susceptible Tuberculosis Treatment. https://www.who.int/publications-detail-redirect/9789240048126 (accessed Sept 15, 2022).

3. Anti-TB drug concentrations and drug-associated toxicities among TB/HIV-coinfected patients

4. Mycobacterium tuberculosis WhiB3 Responds to Vacuolar pH-induced Changes in Mycothiol Redox Potential to Modulate Phagosomal Maturation and Virulence

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