Site-specific Conjugation of 6 DOTA Chelators to a CA19-9-targeting scFv-Fc Antibody for Imaging and Therapy-Reference-Cited by-同舟云学术

Site-specific Conjugation of 6 DOTA Chelators to a CA19-9-targeting scFv-Fc Antibody for Imaging and Therapy

Published:2023-07-18 Issue:15 Volume:66 Page:10604-10616
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Li-An¹,Yu Yueh-Hsiang¹,Tian Wei-Ting¹,Lin Wei-Chen¹,Grauffel Cédric¹,Wu Chun-Yi²^ORCID,Chen Chuan-Lin²,Lim Carmay³^ORCID,Chu Hsing-Mao¹,Chang Tse-Wen¹^ORCID,Peng Chi-Jiun¹

Affiliation:

1. Immunwork, Inc., Academia Rd., Sec. 1, Nangang, Taipei 11571, Taiwan

2. Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Beitou, Taipei 112, Taiwan

3. Institute of Biomedical Sciences, Academia Sinica, Academia Road, Taipei 115, Taiwan

Funder

Ministry of Science and Technology, Taiwan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00753

Reference44 articles.

1. Radiotheranostics: a roadmap for future development

2. Clinical Pharmacology of Radiotheranostics in Oncology

3. Aligning physics and physiology: Engineering antibodies for radionuclide delivery

4. Site-Specifically Labeled Immunoconjugates for Molecular Imaging—Part 1: Cysteine Residues and Glycans

5. Site-Specifically Labeled Immunoconjugates for Molecular Imaging—Part 2: Peptide Tags and Unnatural Amino Acids

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