Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead-Reference-Cited by-同舟云学术

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead

Published:2024-02-09 Issue:4 Volume:67 Page:2369-2378
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dayan Elshan N. G. R.¹,Wolff Karen C.¹,Riva Laura¹,Woods Ashley K.¹,Grabovyi Gennadii¹^ORCID,Wilson Katy¹,Pedroarena James¹,Ghorai Sourav¹,Nazarian Armen¹,Weiss Frank¹,Liu Yuyin¹,Mazumdar Wrickban¹,Song Lirui¹,Okwor Neechi¹,Malvin Jacqueline¹,Bakowski Malina A.¹,Beutler Nathan²,Kirkpatrick Melanie G.¹,Gebara-Lamb Amal¹,Huang Edward¹,Nguyen-Tran Vân T. B.¹,Chi Victor¹,Li Shuangwei¹,Rogers Thomas F.²,McNamara Case W.¹^ORCID,Gupta Anil Kumar¹^ORCID,Rahimi Alireza¹,Chen Jian Jeffrey¹,Joseph Sean B.¹^ORCID,Schultz Peter G.¹³^ORCID,Chatterjee Arnab K.¹^ORCID

Affiliation:

1. Calibr at Scripps Research Institute, 11119 North Torrey Pines Road, La Jolla, California 92037, United States

2. Department of Immunology and Microbiology, The Scripps Research Institute, 10466 North Torrey Pines Road, La Jolla, California 92037, United States

3. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

Funder

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01938

Reference20 articles.

1. World Health Organization, WHO COVID-19 Dashboard, https://covid19.who.int/ (accessed September, 27, 2023).

2. Tracking the COVID-19 vaccines: The global landscape

3. Gilead, Veklury home page, https://www.veklury.com/ (accessed September 27, 2023).

4. Pfizer, Paxlovid home page, https://www.paxlovid.com/ (accessed September 27, 2023).

5. Shionogi, Xocova home page, https://www.shionogi.com/global/en/news/2023/04/20230404.html (accessed September 27, 2023).

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis at the Interface of Chemistry and Biology;Accounts of Chemical Research;2024-08-28

2. Progress in Research on Inhibitors Targeting SARS-CoV-2 Main Protease (M^pro);ACS Omega;2024-08-02

3. Lessons learnt from broad-spectrum coronavirus antiviral drug discovery;Expert Opinion on Drug Discovery;2024-07-30

4. Nirmatrelvir: From Discovery to Modern and Alternative Synthetic Approaches;Processes;2024-06-17

5. Correction to “Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead”;Journal of Medicinal Chemistry;2024-06-14