Small Molecule Benzothiophene with In Vivo Efficacy in a Mouse Model of Drug-Resistant Enterococcus faecium Infection

Author:

Gallardo-Macias Ricardo1,Russo Riccardo2,Sherwood Matthew1,Jaskowski Mark1,Nasser Wissam1,Sharma Pankaj1,Tuckman Margareta2,Singleton Eric2,Ho Hsin Pin3,Park Steven3,Patel Jimmy S.1,George Amir1,Perlin David3,Zimmerman Matthew D.3,Connell Nancy2,Freundlich Joel S.12ORCID

Affiliation:

1. Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States

2. Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States

3. Public Health Research Institute, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Reference19 articles.

1. World Health Organization. Global antimicrobial resistance and use surveillance system (GLASS) report, 2022.

2. Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

3. Multistate Point-Prevalence Survey of Health Care–Associated Infections

4. Murray, B. E.; Miller, W. R. Treatment of enterococcal infections, 2022 https://www.uptodate.com/contents/treatment-of-enterococcal-infections. (accessed September 26, 2023)

5.

Global prevalence of antibiotic resistance in blood-isolated Enterococcus faecalis and Enterococcus faecium: a systematic review and meta-analysis

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