Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library-Reference-Cited by-同舟云学术

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Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library

Published:2023-12-20 Issue:1 Volume:67 Page:620-642
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Park Suhyeorn¹,Fan Jiayi¹,Chamakuri Srinivas²,Palaniappan Murugesan²,Sharma Kiran²,Qin Xuan²^ORCID,Wang Jian²,Tan Zhi¹²,Judge Allison¹,Hu Liya¹,Sankaran Banumathi³,Li Feng²,Prasad B. V. Venkataram¹,Matzuk Martin M.¹²^ORCID,Palzkill Timothy¹^ORCID

Affiliation:

1. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States

2. Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas 77030, United States

3. Berkeley Center for Structural Biology, Advanced Light Source, Lawrence Berkeley National Lab, Berkeley, California 94720, United States

Funder

Welch Foundation

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Cancer Prevention and Research Institute of Texas

Office of Science

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01834

Reference85 articles.

1. Antibacterial resistance worldwide: causes, challenges and responses

2. Fourteen years in resistance

3. The β-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter

4. β-lactam antibiotics: An overview from a medicinal chemistry perspective

5. Carbapenems: Past, Present, and Future

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