Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer-Reference-Cited by-同舟云学术

Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer

Published:2023-12-26 Issue:1 Volume:67 Page:420-432
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Yazhou¹,Wang Chao¹,Liu Tingting¹,Qi Hongyun¹,Chen Shan¹,Cai Xin¹,Zhang Man¹,Aliper Alex²^ORCID,Ren Feng¹^ORCID,Ding Xiao¹^ORCID,Zhavoronkov Alex¹²^ORCID

Affiliation:

1. Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China

2. Insilico Medicine AI Limited, Masdar City 145748, Abu Dhabi, United Arab Emirates

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01476

Reference57 articles.

1. Cancer statistics, 2023

2. PARP inhibitor resistance in breast and gynecological cancer: Resistance mechanisms and combination therapy strategies

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5. Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

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