Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes-Reference-Cited by-同舟云学术

Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes

Published:2023-07-03 Issue:13 Volume:66 Page:9095-9119
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bonazzi Simone¹^ORCID,Gray Audrey²,Thomsen Noel M.¹,Biag Jonathan²,Labbe-Giguere Nancy¹,Keaney Erin P.¹,Malik Hasnain A.¹,Sun Yingchuan¹,Nunez Jill¹,Karki Rajeshri G.¹^ORCID,Knapp Mark³,Elling Robert³,Fuller John⁴,Pardee Gwynn⁴,Craig Lucas²,Capre Ketthsy²,Salas Sarah²,Gorde Aakruti²,Liang Guiqing⁵,Lubicka Danuta⁶,McTighe Stephanie M.²,Goold Carleton²,Liu Shanming⁷,Deng Lin⁵,Hong Jin⁸,Fekete Alexander⁸,Stadelmann Pascal⁹,Frieauff Wilfried⁹,Elhajouji Azeddine⁹,Bauer Daniel⁹^ORCID,Lerchner Andreas¹⁰,Radetich Branko¹,Furet Pascal¹⁰,Piizzi Grazia¹,Burdette Doug⁵,Wilson Christopher J.²,Peukert Stefan¹,Hamann Lawrence G.¹,Murphy Leon O.⁷,Curtis Daniel²

Affiliation:

1. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States

2. Neuroscience, Novartis Institutes for BioMedical Research, 22 Windsor Street, Cambridge, Massachusetts 02139, United States

3. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5959 Horton St, Emeryville, California 94608, United States

4. Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, 5959 Horton St, Emeryville, California 94608, United States

5. Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

6. Global Drug Development/Technical Research and Development, Novartis Institutes for BioMedical Research, 700 Main Street, Cambridge, Massachusetts 02139, United States

7. Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States

8. Preclinical Safety, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

9. Preclinical Safety, Novartis Institutes for BioMedical Research, Fabrikstrasse 28, 4056 Basel, Switzerland

10. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Fabrikstrasse 22, 4056 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00705

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