Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity

Author:

Kim Gibae1,Hou Xiyan12,Byun Woong Sub13,Kim Gyudong14,Jarhad Dnyandev B.1,Lee Grim1,Hyun Young Eum1,Yu Jinha15,Lee Chang Soo1,Qu Shuhao1,Warnick Eugene6,Gao Zhan-Guo6,Kim Ji Yong7,Ji Seunghee8,Shin Hyunwoo8,Choi Jong-Ryoul8,Jacobson Kenneth A.6ORCID,Lee Hyuk Woo7,Lee Sang Kook1ORCID,Jeong Lak Shin17ORCID

Affiliation:

1. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea

2. College of Life Science, Dalian Minzu University, Dalian 116600, People’s Republic of China

3. Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States

4. College of Pharmacy & Research Institute of Drug Development, Chonnam National University, Gwangju 61186, Republic of Korea

5. College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, South Korea

6. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892, United States

7. Future Medicine Company Limited, Seoul 06665, Republic of Korea

8. HK Inno.N Corporation, Seoul 04551, Republic of Korea

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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