Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility-Reference-Cited by-同舟云学术

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Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility

Published:2018-11-05 Issue:24 Volume:61 Page:11169-11182
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Naylor Matthew R.¹^ORCID,Ly Andrew M.¹,Handford Mason J.¹,Ramos Daniel P.¹,Pye Cameron R.¹,Furukawa Akihiro²,Klein Victoria G.¹,Noland Ryan P.¹,Edmondson Quinn¹,Turmon Alexandra C.¹,Hewitt William M.¹,Schwochert Joshua¹,Townsend Chad E.¹,Kelly Colin N.¹,Blanco Maria-Jesus³^ORCID,Lokey R. Scott¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States

2. Modality Research Laboratories, Daiichi Sankyo Company, Ltd., 1-2-58 Hiromachi, Shingawa-ku, Tokyo 140-8710, Japan

3. Sage Therapeutics, 215 First Street, Suite 220, Cambridge, Massachusetts 02142, United States

Funder

Eli Lilly and Company

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01259

Reference97 articles.

1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

2. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

3. Lipophilicity in drug discovery

4. Lipophilicity and biomimetic properties to support drug discovery

5. Hydrophobicity and Central Nervous System Agents: On the Principle of Minimal Hydrophobicity in Drug Design

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