Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo-Reference-Cited by-同舟云学术

Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

Published:2018-09-18 Issue:19 Volume:61 Page:8613-8624
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pan Peichen¹,Chen Jiean²,Li Xijian²,Li Miyang²,Yu Huidong³,Zhao Jean J.⁴⁵,Ni Jing⁴⁵,Wang Xuwen¹,Sun Huiyong¹^ORCID,Tian Sheng⁶,Zhu Feng¹^ORCID,Liu Feng⁶^ORCID,Huang Yong²^ORCID,Hou Tingjun¹⁷^ORCID

Affiliation:

1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China

2. State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University, Shenzhen Graduate School, Shenzhen, Guangdong 518055, China

3. Rongene Pharma Co., Ltd., Guangzhou, Guandong 510663, China

4. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States

5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States

6. College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China

7. State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Commission

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00498

Reference40 articles.

1. Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

2. The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

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