Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties

Author:

Agnetta Luca1,Bermudez Marcel2ORCID,Riefolo Fabio34,Matera Carlo34ORCID,Claro Enrique5,Messerer Regina1,Littmann Timo6,Wolber Gerhard2ORCID,Holzgrabe Ulrike1ORCID,Decker Michael1ORCID

Affiliation:

1. Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, Am Hubland, 97074 Würzburg, Germany

2. Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Straße 2 + 4, 14195 Berlin, Germany

3. Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute for Science and Technology, Carrer Baldiri Reixac 15-21, 08028 Barcelona, Spain

4. Network Biomedical Research Center in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), 50018 Zaragoza, Spain

5. Institut de Neurociències (INc) and Departament de Bioquímica i Biologia Molecular, Unitat de Bioquímica de Medicina, Universitat Autònoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain

6. Institute of Pharmacy, University of Regensburg, Universitätstraße 31, 93053 Regensburg, Germany

Funder

Elitenetzwerk Bayern

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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