Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents-Reference-Cited by-同舟云学术

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Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents

Published:2018-11-01 Issue:23 Volume:61 Page:10753-10766
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zorbaz Tamara¹,Malinak David²³,Maraković Nikola¹,Maček Hrvat Nikolina¹,Zandona Antonio¹,Novotny Michal²³,Skarka Adam²,Andrys Rudolf²,Benkova Marketa³,Soukup Ondrej³,Katalinić Maja¹,Kuca Kamil²^ORCID,Kovarik Zrinka¹,Musilek Kamil²³^ORCID

Affiliation:

1. Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, HR-10000 Zagreb, Croatia

2. Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003 Hradec Kralove, Czech Republic

3. Biomedical Research Center, University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic

Funder

Grantov? Agentura Cesk? Republiky

Hrvatska Zaklada za Znanost

Pr?rodovedeck? fakulta, Univerzita Hradec Kr?lov?

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01398

Reference66 articles.

1. Neuropharmacological Mechanisms of Nerve Agent-induced Seizure and Neuropathology 1 1The animals used in studies performed in, or sponsored by, this Institute were handled in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals, proposed by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council, DHHA, National Institute of Health Publication #85–23, 1985, and the Animal Welfare Act of 1966, as amended. The opinions, or assertions contained herein are the private views of the authors, and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense.

2. Pharmacokinetics and pharmacodynamics of some oximes and associated therapeutic consequences: a critical review

3. ACETYLCHOLINESTERASE

4. A Comparison of the Ability of a New Bispyridinium Oxime—1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane Dibromide and Currently used Oximes to Reactivate Nerve Agent-inhibited Rat Brain Acetylcholinesterase byIn VitroMethods

5. Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent

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2. Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats;Chemico-Biological Interactions;2024-08

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4. Microscopic growth of pyridinium oxime based amphipathic on graphite: Effect of relative position of substituents;Journal of Surfactants and Detergents;2024-07-08

5. New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics;Biomolecules;2024-06-11

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