Why Some Targets Benefit from beyond Rule of Five Drugs-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Why Some Targets Benefit from beyond Rule of Five Drugs

Published:2019-06-12 Issue:22 Volume:62 Page:10005-10025
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Egbert Megan¹,Whitty Adrian²^ORCID,Keserű György M.³,Vajda Sandor¹²^ORCID

Affiliation:

1. Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, United States

2. Department of Chemistry, Boston University, Boston, Massachusetts 02215, United States

3. Medicinal Chemistry Research Group, Research Center for Natural Sciences, Magyar Tudósok krt. 2, H-1117 Budapest, Hungary

Funder

National Institute of General Medical Sciences

Nemzeti Kutat?si Fejleszt?si ?s Innov?ci?s Hivatal

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01732

Reference85 articles.

1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

2. Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs

3. Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

4. Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection

5. How proteins bind macrocycles

Cited by 74 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evaluation of the in vivo acute toxicity and in vitro genotoxicity and mutagenicity of synthetic β-carboline alkaloids with selective cytotoxic activity against ovarian and breast cancer cell lines;Mutation Research - Genetic Toxicology and Environmental Mutagenesis;2024-10

2. Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?;Frontiers in Molecular Neuroscience;2024-04-15

3. Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis;The Journal of Organic Chemistry;2024-03-20

4. Expanding FTMap for Fragment-Based Identification of Pharmacophore Regions in Ligand Binding Sites;Journal of Chemical Information and Modeling;2024-03-08

5. Investigating the effect of polymerase inhibitors on cellular proliferation: Computational studies, cytotoxicity, CDK1 inhibitory potential, and LC‐MS/MS cancer cell entrapment assays;Chemical Biology & Drug Design;2024-03

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3