Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer

Author:

Kim Jina1,Song Jaeyoung1,Ji Hyun Dong,Yoo Eun Kyung,Lee Jae-Eon2,Lee Sang Bong1,Oh Ji Min,Lee Seungmi,Hwang Ji Sun1,Yoon Heeseok1,Kim Dong-Su1ORCID,Lee Su-Jeong1,Jeong Minseon1,Lee Sungwoo1,Kim Kyung-Hee1,Choi Hueng-Sik3,Lee Sang Woo,Park Keun-Gyu4,Lee In-Kyu4,Kim Seong Heon1,Hwang Hayoung1,Jeon Yong Hyun5ORCID,Chin Jungwook1ORCID,Cho Sung Jin1ORCID

Affiliation:

1. New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, South Korea

2. Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Pusan 50463, South Korea

3. National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, South Korea

4. Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea

5. Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, South Korea

Funder

Korea Drug Development Fund

Korea Health Industry Development Institute

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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