Discovery and Structure–Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2′-Oxidase-Reference-Cited by-同舟云学术

Discovery and Structure–Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2′-Oxidase

Published:2018-10-10 Issue:22 Volume:61 Page:9952-9965
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Oh Sangmi¹^ORCID,Park Yumi¹,Engelhart Curtis A.²,Wallach Joshua B.²,Schnappinger Dirk²,Arora Kriti¹,Manikkam Michelle¹,Gac Brian¹,Wang Hongwu³,Murgolo Nicholas³,Olsen David B.³,Goodwin Michael¹,Sutphin Michelle¹,Weiner Danielle M.¹,Via Laura E.¹⁴,Boshoff Helena I. M.¹^ORCID,Barry Clifton E.¹⁴^ORCID

Affiliation:

1. Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States

2. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10021, United States

3. Discovery Research, Merck & Company, Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States

4. Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7935, South Africa

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00883

Reference53 articles.

1. New drugs and perspectives for new anti-tuberculosis regimens

2. Accelerating the development of therapeutic strategies for drug-resistant tuberculosis

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