Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a “Tail Switching” Strategy on a Piperazinyl Azetidine Skeleton

Author:

Chen Zhen12ORCID,Mori Wakana3,Deng Xiaoyun1,Cheng Ran1,Ogasawara Daisuke4,Zhang Genwei5,Schafroth Michael A.4ORCID,Dahl Kenneth1,Fu Hualong1,Hatori Akiko3,Shao Tuo1,Zhang Yiding3,Yamasaki Tomoteru3,Zhang Xiaofei1,Rong Jian1,Yu Qingzhen1,Hu Kuan3,Fujinaga Masayuki3,Xie Lin3,Kumata Katsushi3,Gou Yuancheng6,Chen Jingjin6,Gu Shuyin6,Bao Liang6,Wang Lu1,Collier Thomas Lee1,Vasdev Neil1ORCID,Shao Yihan5ORCID,Ma Jun-An2ORCID,Cravatt Benjamin F.4ORCID,Fowler Christopher7,Josephson Lee1,Zhang Ming-Rong3ORCID,Liang Steven H.1ORCID

Affiliation:

1. Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, Massachusetts 02114, United States

2. Department of Chemistry, School of Science, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China

3. Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan

4. The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, SR107 10550 North Torrey Pines Road, La Jolla, California 92037, United States

5. Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States

6. ChemShuttle, Inc., 1699 Huishan Blvd., Wuxi, Jiangsu 214174, China

7. Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden

Funder

Vetenskapsr?det

China Scholarship Council

National Institute on Drug Abuse

National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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