New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective (Z)-N-tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment-Reference-Cited by-同舟云学术

New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective (Z)-N-tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment

Published:2019-02-04 Issue:4 Volume:62 Page:2184-2201
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chioua Mourad¹,Martínez-Alonso Emma²,Gonzalo-Gobernado Rafael³,Ayuso Maria I.³,Escobar-Peso Alejandro¹²,Infantes Lourdes⁴,Hadjipavlou-Litina Dimitra⁵,Montoya Juan J.⁶,Montaner Joan³⁷,Alcázar Alberto²^ORCID,Marco-Contelles José¹^ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry, IQOG, CSIC, C/Juan de la Cierva 3, Madrid 28006, Spain

2. Department of Investigation, IRYCIS, Hospital Ramón y Cajal, Ctra. Colmenar km 9.1, Madrid 28034, Spain

3. Neurovascular Research Group, Institute of Biomedicine of Seville, IBiS, Hospital Universitario Virgen del Rocío, Av. Manuel Siurot s/n, Seville 41013, Spain

4. Institute of Physical-Chemistry Rocasolano, CSIC, C/Serrano 119, Madrid 28006, Spain

5. Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece

6. Isquaemia Biotech SL, Scientific Technological Park, C/Astrónoma Cecilia Payne s/n, Córdoba 14014, Spain

7. Department of Neurology, Hospital Universitario Virgen Macarena, Av. Doctor Fedriani 3, Seville 41007, Spain

Funder

European Regional Development Fund

Ministerio de Econom?a y Competitividad

Universidad Camilo Jos? Cela

Instituto de Salud Carlos III

Gobierno de la Comunidad de Madrid

Isquaemia Biotech

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01987

Reference60 articles.

1. The complexity of neurobiological processes in acute ischemic stroke

2. Chan, P. H. In Cellular Antioxidant Defense Mechanisms; Chow, C. K., Ed. CRC Press: Boca Raton, FL, 1988; Vol. 3, pp 89–109.

3. Nitrones as therapeutics

4. The spin trap, α-phenylN-tert-butylnitrone, inhibits the oxidative modification of low density lipoprotein

5. The effect of spin traps on phenylhydrazine-induced haemolysis

Cited by 40 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer's disease;European Journal of Medicinal Chemistry;2024-12

2. In Vitro Modulation of Autophagy by New Antioxidant Nitrones as a Potential Therapeutic Approach for the Treatment of Ischemic Stroke;Antioxidants;2024-08-03

3. Synthesis of Quinolinoneylnitrones and Coumarinylnitrones via a Cascade Hydroamination and Aza-MBH-Type Reaction;The Journal of Organic Chemistry;2024-07-04

4. Efficacy assessment of novel methanimine derivatives in chronic constriction injury-induced neuropathic model: An in-vivo, ex-vivo and In-Silico approach;European Journal of Pharmaceutical Sciences;2024-07

5. Palladium-Catalyzed Synthesis of Nitrones Via Redox Cross-Coupling of Nitro Compounds and Alcohols;The Journal of Organic Chemistry;2024-06-25