Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

Published:2019-01-11 Issue:3 Volume:62 Page:1274-1290
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Romagnoli Romeo¹^ORCID,Prencipe Filippo¹,Oliva Paola¹,Baraldi Stefania¹,Baraldi Pier Giovanni¹,Schiaffino Ortega Santiago²,Chayah Mariem²,Kimatrai Salvador Maria²,Lopez-Cara Luisa Carlota²^ORCID,Brancale Andrea³^ORCID,Ferla Salvatore³,Hamel Ernest⁴,Ronca Roberto⁵,Bortolozzi Roberta⁶,Mariotto Elena⁶,Mattiuzzo Elena⁶,Viola Giampietro⁶⁷

Affiliation:

1. Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy

2. Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Campus de Cartuja s/n, 18071 Granada, Spain

3. School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K.

4. Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States

5. Dipartimento di Medicina Molecolare e Traslazionale Unità di Oncologia Sperimentale ed Immunologia, Università di Brescia, 25123 Brescia, Italy

6. Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, Università di Padova, 35131 Padova, Italy

7. Istituto di Ricerca Pediatrica (IRP), Corso Stati Uniti 4, 35128 Padova, Italy

Funder

Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía

Welsh Government

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01391

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