Identification and Profiling of Hydantoins—A Novel Class of Potent Antimycobacterial DprE1 Inhibitors-Reference-Cited by-同舟云学术

Identification and Profiling of Hydantoins—A Novel Class of Potent Antimycobacterial DprE1 Inhibitors

Published:2018-11-30 Issue:24 Volume:61 Page:11221-11249
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rogacki Maciej K.¹²,Pitta Eleni¹²,Balabon Olga¹²,Huss Sophie²,Lopez-Roman Eva Maria²,Argyrou Argyrides³^ORCID,Blanco-Ruano Delia²,Cacho Monica²,Vande Velde Christophe M. L.⁴,Augustyns Koen¹^ORCID,Ballell Lluis²,Barros David²^ORCID,Bates Robert H.²,Cunningham Fraser²,Van der Veken Pieter¹^ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium

2. Diseases of the Developing World (DDW), Tres Cantos Medicines Development Campus (TCMDC), GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain

3. Platform Technology and Science, GlaxoSmithKline, Stevenage SG1 2NY, U.K.

4. Faculty of Applied Engineering, Advanced Reactor Technology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerpen, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01356

Reference45 articles.

1. World Health Organization. Global Tuberculosis Report 2018. http://www.who.int/tb/publications/global_report/en/ (accessed Nov 20, 2018).

2. Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

3. Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1

4. Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

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