Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design-Reference-Cited by-同舟云学术

Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design

Published:2018-11-01 Issue:24 Volume:61 Page:11074-11100
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hobson Adrian D.¹^ORCID,Judge Russell A.²,Aguirre Ana L.²,Brown Brian S.²,Cui Yifang³,Ding Ping¹,Dominguez Eric¹,DiGiammarino Enrico²,Egan David A.²,Freiberg Gail M.²,Gopalakrishnan Sujatha M.²,Harris Christopher M.¹,Honore Marie P.²,Kage Karen L.²,Kapecki Nicolas J.²,Ling Christopher²,Ma Junli²,Mack Helmut³,Mamo Mulugeta²,Maurus Stefan³,McRae Bradford¹,Moore Nigel S.¹,Mueller Bernhard K.³,Mueller Reinhold³,Namovic Marian T.²,Patel Kaushal²,Pratt Steve D.²,Putman C. Brent²,Queeney Kara L.¹,Sarris Kathy K.²,Schaffter Lisa M.¹,Stoll Vincent²,Vasudevan Anil²^ORCID,Wang Lei¹,Wang Lu¹,Wirthl William¹,Yach Kimberly¹

Affiliation:

1. AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States

2. AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

3. AbbVie Deutschland GmbH & Co. KG, Knollstrasse 50, 67061, Ludwigshafen, Germany

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01098

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3. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

4. A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

5. Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

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