Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist-Reference-Cited by-同舟云学术

Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist

Published:2018-08-21 Issue:23 Volume:61 Page:10415-10439
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Schnute Mark E.^ORCID,Wennerstål Mattias¹,Alley Jennifer,Bengtsson Martin¹,Blinn James R.,Bolten Charles W.,Braden Timothy,Bonn Tomas¹,Carlsson Bo¹,Caspers Nicole²,Chen Ming²,Choi Chulho²,Collis Leon P.,Crouse Kimberly,Färnegårdh Mathias¹,Fennell Kimberly F.²,Fish Susan,Flick Andrew C.²,Goos-Nilsson Annika¹,Gullberg Hjalmar¹,Harris Peter K.,Heasley Steven E.²,Hegen Martin,Hromockyj Alexander E.,Hu Xiao,Husman Bolette¹,Janosik Tomasz¹,Jones Peter,Kaila Neelu,Kallin Elisabet¹,Kauppi Björn¹,Kiefer James R.,Knafels John²,Koehler Konrad¹,Kruger Lars¹,Kurumbail Ravi G.²,Kyne Robert E.²,Li Wei,Löfstedt Joakim¹,Long Scott A.,Menard Carol A.²,Mente Scot,Messing Dean,Meyers Marvin J.,Napierata Lee,Nöteberg Daniel¹,Nuhant Philippe²^ORCID,Pelc Matthew J.,Prinsen Michael J.,Rhönnstad Patrik¹,Backström-Rydin Eva¹,Sandberg Johnny¹,Sandström Maria¹,Shah Falgun,Sjöberg Maria¹,Sundell Aron¹,Taylor Alexandria P.²,Thorarensen Atli,Trujillo John I.²,Trzupek John D.,Unwalla Ray^ORCID,Vajdos Felix F.²,Weinberg Robin A.,Wood David C.,Xing Li,Zamaratski Edouard¹,Zapf Christoph W.,Zhao Yajuan,Wilhelmsson Anna¹,Berstein Gabriel

Affiliation:

1. Karo Bio AB (now Karo Pharma AB), 111 48 Stockholm, Sweden

2. Medicine Design, Pfizer Inc., Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00392

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