Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A–E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium-Reference-Cited by-同舟云学术

Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A–E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium

Published:2018-07-17 Issue:14 Volume:61 Page:6364-6378
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Al-Awadhi Fatma H.¹²,Gao Bowen³,Rezaei Mohammad A.¹⁴,Kwan Jason C.¹,Li Chenglong¹,Ye Tao³^ORCID,Paul Valerie J.⁵,Luesch Hendrik¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait

3. State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen, 518055, China

4. Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States

5. Smithsonian Marine Station, Fort Pierce, 701 Seaway Drive, Fort Pierce, Florida 34949, United States

Funder

National Cancer Institute

Shenzhen Science and Technology Innovation Committee

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00885

Reference69 articles.