Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB-Reference-Cited by-同舟云学术

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Published:2018-06-26 Issue:15 Volume:61 Page:6592-6608
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cleghorn Laura A. T.¹,Ray Peter C.¹,Odingo Joshua²,Kumar Anuradha²,Wescott Heather²,Korkegian Aaron²,Masquelin Thierry³,Lopez Moure Abraham¹,Wilson Caroline¹,Davis Susan¹,Huggett Margaret¹,Turner Penelope¹,Smith Alasdair¹,Epemolu Ola¹,Zuccotto Fabio¹,Riley Jennifer¹,Scullion Paul¹,Shishikura Yoko¹,Ferguson Liam¹,Rullas Joaquin⁴,Guijarro Laura⁴,Read Kevin D.¹^ORCID,Green Simon R.¹^ORCID,Hipskind Phil³,Parish Tanya²^ORCID,Wyatt Paul G.¹^ORCID

Affiliation:

1. Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom

2. TB Discovery Research, Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States

3. Eli Lilly and Company, Discovery Chemistry Research, Lilly Corporate Centre, MC/87/02/203, G17, Indianapolis, Indiana 46285, United States

4. Diseases of the Developing World, GlaxoSmithKline, Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid Spain

Funder

Bill and Melinda Gates Foundation

Wellcome Trust

Eli Lilly and Company

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00172