Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2-Reference-Cited by-同舟云学术

Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2

Published:2018-11-20 Issue:3 Volume:62 Page:1125-1137
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wu Xiaoqin¹,Xu Gang²,Li Xiaobo¹²,Xu Weiren²,Li Qianjin¹,Liu Wei²,Kirby Karen A.³,Loh Mignon L.⁴,Li Jun⁵,Sarafianos Stefan G.³,Qu Cheng-Kui¹²^ORCID

Affiliation:

1. Department of Pediatrics, Division of Hematology/Oncology, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia 30322, United States

2. Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, United States

3. Department of Pediatrics, Laboratory of Biochemical Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States

4. Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of California, San Francisco, San Francisco, California 94122, United States

5. School of Pharmacy, Anhui Medical University, Hefei 230032, China

Funder

National Institute of Child Health and Human Development

Hyundai Hope On Wheels

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00513

Reference43 articles.

1. The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling