Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu7 Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)-Reference-Cited by-同舟云学术

Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu7 Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)

Published:2019-01-04 Issue:3 Volume:62 Page:1690-1695
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Reed Carson W.,Yohn Samantha E.,Washecheck Jordan P.,Roenfanz Hanna F.,Quitalig Marc C.,Luscombe Vincent B.,Jenkins Matthew T.,Rodriguez Alice L.,Engers Darren W.,Blobaum Anna L.,Conn P. Jeffrey¹,Niswender Colleen M.¹,Lindsley Craig W.^ORCID

Affiliation:

1. Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

Funder

U.S. Department of Defense

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01810

Reference24 articles.

1. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease