Improved Conjugation, 64-Cu Radiolabeling, in Vivo Stability, and Imaging Using Nonprotected Bifunctional Macrocyclic Ligands: Bis(Phosphinate) Cyclam (BPC) Chelators

Author:

David Tomáš12,Hlinová Veronika1,Kubíček Vojtěch1ORCID,Bergmann Ralf2,Striese Franziska2,Berndt Nicole34,Szöllősi Dávid5,Kovács Tibor67,Máthé Domokos5,Bachmann Michael289,Pietzsch Hans-Jürgen2,Hermann Petr1ORCID

Affiliation:

1. Department of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 40 Prague, Czech Republic

2. Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany

3. Partner Site Dresden, German Cancer Consortium (DKTK), Fetscherstrasse 74, 01307 Dresden, Germany

4. German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

5. Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó utca 37−47, H-1094 Budapest, Hungary

6. Institute of Radiochemistry and Radioecology, University of Pannonia, Egyetem St. 10, H-8200 Veszprém, Hungary

7. Social Organization for Radioecological Cleanliness, P.O. Box 158, H-8200 Veszprém, Hungary

8. Tumor Immunology, University Cancer Center (UCC), “Carl Gustav Carus” Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany

9. National Center for Tumor Diseases (NCT), “Carl Gustav Carus” Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany

Funder

Deutscher Akademischer Austauschdienst

Grantov? Agentura Cesk? Republiky

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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