Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance-Reference-Cited by-同舟云学术

Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance

Published:2018-07-05 Issue:14 Volume:61 Page:5988-6001
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Bo¹,Ma Li-Ying¹,Wang Jing-Quan²,Lei Zi-Ning²,Gupta Pranav²,Zhao Yuan-Di¹,Li Zhong-Hua¹,Liu Ying¹,Zhang Xin-Hui¹,Li Ya-Nan¹,Zhao Bing¹,Chen Zhe-Sheng²,Liu Hong-Min¹^ORCID

Affiliation:

1. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China

2. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, New York 11439, United States

Funder

Ministry of Science and Technology of the People's Republic of China

Zhengzhou University

National Natural Science Foundation of China

Henan Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00335