Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester-Reference-Cited by-同舟云学术

Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester

Published:2018-10-31 Issue:23 Volume:61 Page:10463-10472
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Castro-Falcón Gabriel¹,Seiler Grant S.¹²,Demir Özlem²^ORCID,Rathinaswamy Manoj K.³,Hamelin David³,Hoffmann Reece M.³,Makowski Stefanie L.⁴,Letzel Anne-Catrin¹,Field Seth J.⁴,Burke John E.³,Amaro Rommie E.²^ORCID,Hughes Chambers C.¹^ORCID

Affiliation:

1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, United States

2. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States

3. Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 2Y2, Canada

4. School of Medicine, University of California, San Diego, La Jolla, California, 92093, United States

Funder

Howard Hughes Medical Institute

University of California, San Diego

NIH Office of the Director

American Cancer Society

Scripps Institution of Oceanography

Publisher

American Chemical Society (ACS)

Subject