Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus

Author:

Kunkle Trent1,Abdeen Sanofar1,Salim Nilshad1,Ray Anne-Marie1,Stevens Mckayla1,Ambrose Andrew J.2ORCID,Victorino José1,Park Yangshin134,Hoang Quyen Q.134,Chapman Eli2ORCID,Johnson Steven M.1ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, United States

2. Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona 85721, United States

3. Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W. 15th Street, Suite 414, Indianapolis, Indiana 46202, United States

4. Department of Neurology, Indiana University School of Medicine. 635 Barnhill Drive, Indianapolis, Indiana 46202, United States

Funder

University of Arizona

National Institute of General Medical Sciences

Indiana University School of Medicine

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference46 articles.

1. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States, 2013. Centers for Disease Control and Prevention: Atlanta, GA, USA, 2013; p 114.

2. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

3. Platforms for antibiotic discovery

4. New strategies for combating multidrug-resistant bacteria

5. The role of bacterial biofilms in chronic infections

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