Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors-Reference-Cited by-同舟云学术

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors

Published:2018-04-27 Issue:10 Volume:61 Page:4397-4411
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Schuetz Doris A.¹^ORCID,Richter Lars¹^ORCID,Amaral Marta²³,Grandits Melanie¹,Grädler Ulrich²,Musil Djordje²,Buchstaller Hans-Peter⁴,Eggenweiler Hans-Michael⁴,Frech Matthias²,Ecker Gerhard F.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, University of Vienna, UZA 2, Althanstrasse 14, 1090 Vienna, Austria

2. Discovery Technologies, Merck KGaA, Frankfurter Straße 250, 64293 Darmstadt, Germany

3. Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal

4. Medicinal Chemistry, Merck KGaA, 64293 Darmstadt, Germany

Funder

European Commission

European Federation of Pharmaceutical Industries and Associations

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00080

Reference63 articles.

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