Ligand–Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand-Reference-Cited by-同舟云学术

Ligand–Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand

Published:2018-04-13 Issue:9 Volume:61 Page:4020-4029
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kawamura Shuhei,Ito Yoshihiko¹,Hirokawa Takatsugu²,Hikiyama Eriko¹,Yamada Shizuo¹,Shuto Satoshi^ORCID

Affiliation:

1. Center for Pharma-Food Research, Department of Pharmacokinetics and Pharmacodynamics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan

2. Molecular Profiling Research Center for Drug Discovery (MOLPROF), National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koutou-ku, Tokyo 135-0064, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00041

Reference50 articles.

1. Drug–target residence time and its implications for lead optimization

2. Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

3. Drug–target residence time: critical information for lead optimization

4. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action

5. Can the pharmaceutical industry reduce attrition rates?

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