Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition

Author:

Denton Travis T.1ORCID,Srivastava Pramod1,Xia Zuping1ORCID,Chen Gang1,Watson Christy J. W.1,Wynd Alec1,Lazarus Philip1ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington 99202, United States

Funder

Health Sciences and Services Authority of Spokane

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference23 articles.

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2. The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon General, 2014. https://www.surgeongeneral.gov/library/reports/50-years-of-progress/index.html (accessed July 19, 2018).

3. Actual Causes of Death in the United States, 2000

4. National Institute on Drug Abuse. Tobacco, Nicotine, and E-Cigarettes, Is Nicotine Addictive? https://www.drugabuse.gov/publications/research-reports/tobacco/nicotine-addictive (accessed July 02, 2018).

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